Start Denudating


The only published report focusing on the influence of denudation timing did not show any significant influence on the results [3].

Moreover, Balakier and colleagues [14] reported that human oocytes progressively develop the ability for full activation and normal development during the MII arrest stage.

The improvement in fertilization rates was obtained when ICSI was carried out 6–8 hours after the first polar body expulsion.

However, other studies supported different results as no statistically significant differences in the fertilization [3, 4] or the pregnancy rates [2, 6] were found in preincubated oocytes during ICSI cycles.